Wolff T, Berrueta LA, Valente LMM, Barboza RS, Neris RLS, Guimarães-Andrade IP, Assunção-Miranda I, Nascimento AC, Gomes M, Gallo B, Iriondo C. Comprehensive characterisation of polyphenols in leaves and stems of three anti-dengue virus type-2 active Brazilian Faramea species (Rubiaceae) by HPLC-DAD-ESI-MS/MS. Phytochem Anal. 2019 Jan;30(1):62-72.

DOI: 10.1002/pca.2790

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The methanol (MeOH) leaf extracts of the species Faramea bahiensis, F. hyacinthina and F. truncata (Rubiaceae) have previously shown in vitro non-cytotoxic and anti-dengue virus serotype 2 (DENV2) activities in human hepatocarcinoma cell lineage (HepG2). Chemical studies have led to the isolation of major flavonoids, but quite complex fractions of phenolic compounds still remain.